$re = '/(?<Building>\b\d+)\s(?<Street>.*(?:#\d+|No Unit Number))\s(?<City>\b.+),\s(?<State>.{2})\s(?<Zip>\d{5}\b)/m';
$str = '1234 Street Name Unit #225 Harpers Ferry, VA 12345
5547 No Unit Number Jackson Hole, WY 12345
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php