$re = '/(?:(?s:START.*?END)|\/\/.*|\.\s*\w+\b)(*SKIP)(*F)|old/';
$str = '__DATA__
xx START xx old xx END xx --> ignore
xx old xx --> REPLACE !
START xx old --> ignore
xx old xx END --> ignore
xx old xx --> REPLACE !
// xx old --> ignore
xx // xx old --> ignore
xx . old old xx --> ignore first one, replace second one
.
old --> ignore
(old) xx --> REPLACE !
xx old xx --> REPLACE !';
$subst = "new";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php