use strict;
my $str = 'One-1|two-2|Three-3|Four-4|Five-5
Six-6|Seven-7|Eight-8|Nine|Ten-10
Eleven-11|Twelve-12|Thirteen-13|Fourteen-14|Fifteen-15
Sixteen-16|Seventeen-17|Eighteen-18|Nineteen-19|Twenty-20';
my $regex = qr/^(.*?\|){2}|(\|[^|]*){2}$/mp;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html