const regex = /(?:<!--.*?-->|<style[\S\s\n]*?<\/style>|<script[\S\s\n]*?<\/script>|rgb\(\d+,\x20\d+,\x20\d+\))(*SKIP)(*F)|\((.+?)\)\s*again/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(?:<!--.*?-->|<style[\\S\\s\\n]*?<\\\/style>|<script[\\S\\s\\n]*?<\\\/script>|rgb\\(\\d+,\\x20\\d+,\\x20\\d+\\))(*SKIP)(*F)|\\((.+?)\\)\\s*again', 'gm')
const str = `<!-- (Male) -->
<p>(Malē) again</p>
<p style="font-family: "verdana"; font-size: 18px; color: rgb(0, 0, 0);">Malē again</p>
<style>
code {
font-family: "verdana";
font-size: 18px;
color: black;
font-weight: bold !important;
line-height: 1.6 !important;
}
@media (min-width: 1281px) {
code {
font: 24px "verdana" bold !important;
}
}
</style>
<script type="text/javascript">
function googleTranslateElementInit() {
new google.translate.TranslateElement({pageLanguage: 'en'}, 'google_translate_element');
}
</script>`;
const subst = `$1 - again`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions