use strict;
my $str = '4.13723725115740744492e+04,162,1);';
my $regex = qr/[^,]+(?=,162,1\);)/mp;
my $subst = '\'2015-04-02 10:46:28\'';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html