use strict;
my $str = '728,"H !A@Y,HAYE",Marie,François,RAUTUREAU,85,29/05/1856,68;';
my $regex = qr/,(?=[^"]+")/p;
my $subst = '-';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html