$re = '/\.(?!\d)/';
$str = 'a,b,a.b,a.,1,2,1.2,1.,.,11,222,11.222,11.';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php