$re = '/(^.*\?)([^\?].*(?=<))(<\/br>)/m';
$str = 'Hoeveel is vier keer vijfentwintig? Honderd</br>';
$subst = "<span title = \"$2\">$1</span>$3";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php