$re = '/Version\s*(\S+?),/';
$str = '2800 Software (C2800NM-ADVIPSERVICESK9-M), Version 12.4(24)T8, RELEASE SOFTWARE (fc1)';
$subst = "x";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php