use strict;
my $str = 'key:{value}
key:{valu{0}e}
key:{valu
{0}e}
key: {val-u{0}e}
key: {val__[!]
-u{0}{1}e}';
my $regex = qr/^(.*?)([\s:]+)?{([\s\S].*)?.$/mp;
my $subst = '$1,$3';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html