re = /(?:(?<=\D)|\s*\b)0{4}\d*/m
str = 'ANOA 250g 00004689
ANOA 10000g 00000059884
80%c asjw 150000001568
Shivangi000000478761'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html