$re = '/(\d{1,3}\.\d{1,3}\.\d{1,3}\.\d{1,3})(\s*,\s*(\d{1,3}\.\d{1,3}\.\d{1,3}\.\d{1,3}))*/';
$str = '10.1.1.1,123.123.123.123,192.192.192.192';
$subst = "";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php