$re = '/(\S+?)\s*=\s*\"([^\t]+)\"\s*(?>;\s*\n)/U';
$str = 'key_1= "vdsdsalh";
multiline_key = "something
with
many lines";
Key2 = "test with ; symbol";
';
$subst = "^[#;].*";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php