use strict;
my $str = '%d:%d:%d:%s
%d:%d:%s
%d:%s
%f:%d:%s';
my $regex = qr/^(?!.*%[^sd])(?!.*%d.*%d.*%d)(?!.*%s.*%s)(?=.*%s).*$/mp;
my $subst = '\\n';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html