$re = '/(?:^Time_in_seconds\[\d+\]Time_in_seconds$(\R?))+/m';
$str = 'Time_in_seconds[1]Time_in_seconds
Time_in_seconds[123]Time_in_seconds
Time_in_seconds[*]Time_in_seconds
Time_in_seconds[1]Time_in_seconds
Time_in_seconds[2]Time_in_seconds
Time_in_seconds[3]Time_in_seconds';
$subst = "My new line$1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php