$re = '/.*?(?<=CREATED ON )([^>]+)>.*/s';
$str = '</BODY></HTML><FILE CREATED ON 0:32:33 Feb 24, 2009>{several empty lines before the end of document}';
$subst = "$1";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php