use strict;
my $str = '123456789123456789123456789
123456789
1234567
123456781234567812345678.111111111111111
34.345';
my $regex = qr/\d+\.\d*(*SKIP)(*FAIL)|(?!^)(?=(?:\d{3})+(?!\.|\d))/mp;
my $subst = ',';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html