$re = '/\s*-\s*(\(\d{5}\))\s*-\s*(\w{3}\s\d{4}\w?-\d{3}-(?:[^.\s]|\b\s\b)+)\s*-\s*([^.]+\.txt)$/ms';
$str = '201308 - (82608) - MAC 2233-007-Methods of Calculus - Klingler, Lee.txt
201308 - (12345) - ABC 2233L-007-course Name 1 - last, first.txt
@ @ @ @ @ @ 123 abc - a-1 - b-2.txt
201308-(82609) -MAC 2233-007-Methods of Calculus - Klingler, Lee.txt
201308 - (12345)-ABC 2233L-007-course Name-last, first.txt
201308-(12345)-ABC 2233L-007-course Name-last, first.txt';
$subst = " - \1 - \2 - \3";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php