$re = '/^(?:LOG:)(?:[^,]*,){4}(?!00?)([^,]*).*$/m';
$str = 'LOG:69369,1,30,40,80,06,1
LOG:69369,1,30,40,C0,06,1
POS:69453,69576034,-19244227,1,0
LOG:69405,2,30,40,00,06,2
POS:69333,69576024,-19244235,1,0
LOG:69405,2,30,40,C0,06,2 ';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php