$re = '/((?:[\t ]*(?:R|RE|F|FW|FWD):[\t ]*)*)(.*)/mi';
$str = 'RE: RE:Fw: RE:FW: FWD: re: This is a message from a long thread re: asdf
Refund issued: Combination Padlock Lock Gym, School Locker, Sheds, Toolboxes Various Colours
Re: abc123 sent a message about Galvanised U Nails Netting Fencing Staples Chicken Wire Mesh Fences #123123123123
Request #0123456789: Buyer received a refund
Re: johndoe has sent a question about item #456456456456, ending on 03-Mar-19 05:48:20 GMT - Combination Padlock Lock Gym, School Locker, Sheds, Toolboxes Various Colours';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php