$re = '/(?<!guión:\s)([\p{Lu}][\p{Ll}]+\b)/um';
$str = 'guión: El computador. Ángel.';
$subst = "**\1**";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php