$re = '/[{} &+( )" =!.?.:.. / | » © : >< # « , 1 2 3 4 5 6 7 8 9 _ - + ; \[ \] %]/iu';
$str = ' :621 " :621 :1 ;" _ " :594 :25 4 8 0 :23 "സരàµâ€à´•àµà´•ാരàµâ€à´œàµ€à´µà´¨à´•àµà´•ാരàµà´Ÿàµ† à´¶à´®àµà´ªà´³à´‚ അറിയാനàµâ€ à´à´¾à´°àµà´¯à´®à´¾à´°àµâ€à´•àµà´•ൠഅവകാശമàµà´£àµà´Ÿàµà´µà´¿à´µà´°à´¾à´µà´•ാശകമàµà´®àµ€à´·à´¨àµâ€
:621 :4 0 3 0 ;" _ " :551 :16 :3';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php