use strict;
my $str = '1 NameA - DirectionA=[[StreetA @ StreetB,[Lat,Long]]]
1 NameA - DirectionA=[[StreetC @ StreetD,[Lat,Long]], [StreetF @ StreetE,[Lat,Long]]]
1 NameA - DirectionB=[[StreetE @ StreetF,[Lat,Long]], [StreetG @ StreetH,[Lat,Long]]]
2 NameB - DirectionC=[[StreetI @ StreetJ,[Lat,Long]], [StreetK @ StreetL,[Lat,Long]]]
2 NameB - DirectionD=[[StreetM @ StreetN,[Lat,Long]], [StreetO @ StreetP,[Lat,Long]]]';
my $regex = qr/^([\S\s]*?^[^][]*=)\[\[[^][]*\[[^][]*\]\]\K\]\R[^][]*\[(.*)\]$(?!\R\1)/mp;
my $subst = ', \\2]';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html