use strict;
my $str = 'To: ab@domain.tld
Subject: Der Betreff
From: xp@domain.tld
Reply-To: xp@domain.tld
Hier kommt meine Nachricht
To: ab@domain.tld
Subject: Der Betreff
From: xp@domain.tld
Reply-To: xp@domain.tld
Hier kommt meine Nachricht
To: ab@domain.tld
Subject: Der Betreff
From: xp@domain.tld
Reply-To: xp@domain.tld
Hier kommt meine Nachricht';
my $regex = qr/\v+(?=To:)/p;
my $subst = '_';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html