$re = '/(?:(\d*|\D)*(\|)){4}\K/';
$str = 'ID|CategoryID|Category|Title|Summary|Article
###|###|Business|4 Things I Wish I Knew Before Starting My Company|This is where the summary would go|This is where the article would begin';
$subst = "|]";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php