const regex = /(?:(?<=\P{L})(?=(?:\p{Lu}\h+){2}\p{Lu})|\G(?!\A))\p{Lu}\K\h+(?=\p{Lu}(?!\p{L}))/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(?:(?<=\\P{L})(?=(?:\\p{Lu}\\h+){2}\\p{Lu})|\\G(?!\\A))\\p{Lu}\\K\\h+(?=\\p{Lu}(?!\\p{L}))', 'g')
const str = `Welcome to A I: the best W O R L D!
Hi I R is the B O M B for sure: weA É A G R E E Éindeed.`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions