$re = '/(?:(?<=\P{L})(?=(?:\p{Lu}\h+){2}\p{Lu})|\G(?!\A))\p{Lu}\K\h+(?=\p{Lu}(?!\p{L}))/';
$str = 'Welcome to A I: the best W O R L D!
Hi I R is the B O M B for sure: weA É A G R E E Éindeed.';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php