$re = '/(BB(?:\|\d){4,6}\|[^\s|]{3}\|[^\s|]{4}\|)9{2,9}\|9{2,9}(?!\d)/m';
$str = 'XX=BB|3|3|1|1|PLP|KLWE|9999|9999
XX=BB|3|3|1|1|2|PLP|KPOK|99999|99999
999|999|999|9999|999';
$subst = "\g<1>12|21";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php