# If you'd like to omit non-matching lines from the result; add ';d' to the end of the expression.
sed -E 's/[^"](?={{)(.*?)}}[^"]/sads/g;t' <<< "Nemo enim ipsam voluptatem quia {{ voluptas }} labore et {{ dolore }} eum
<a href=\" {{iure}}abc \" dasdas>{{reprehenderit}}<dsa /a> qui <a href=\"{{ news }}\">{{smart}}</a> ea.\"
"
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for SED, please visit: https://www.gnu.org/software/sed/manual/html_node/The-_0022s_0022-Command.html