use strict;
my $str = 'Nemo enim ipsam voluptatem quia {{ voluptas }} labore et {{ dolore }} eum
<a href=" {{iure}}abc " dasdas>{{reprehenderit}}<dsa /a> qui <a href="{{ news }}">{{smart}}</a> ea."
';
my $regex = qr/[^"](?={{)(.*?)}}[^"]/p;
my $subst = 'sads';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html