use strict;
my $str = 'abA0@67
abA0@6
abA0@678
abA0at678
';
my $regex = qr/^.(?=.*[a-z].)(?=.*[A-Z].)(?=.*[0-9].)(?=.*[@#$,.].).{6,}$/mp;
my $subst = '0$1';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html