$re = '/(?<=[a-zA-Z])([\d]+)(?=[a-zA-Z])(?=(?:[^~]*~[^~]*~[^~]*)*$)/';
$str = '5n7x Jahalducro) ~P4J99UMH9~ (MD) auntud C D T)';
$subst = " $1 ";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php