$re = '/^\d+\,(?:\d+\,?)+$/m';
$str = '1,2,3,5
1,23
1|46|6778|567
1,278,3780,50
57,,,,,,578678,678,67,678,678,,,,,6,78,6';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php