$re = '~<br(?: /)?>\K\s+~i';
$str = 'This is a space after a <br> break.
This is 2 spaces after a <br> break.
This is a tab after a <br> break.
This is a newline after a <br>
break;';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php