$re = '/(?:\b(?:DR|prof)\.[^\S\n]+)+|[^\w\s]+/m';
$str = 'DR. Tida.
prof. Sina.
DR. prof. Tida.';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php