$re = '/<iframe.+src="https?:\/\/(?:www.)?youtu\.?be(?:\.com)?.+<\/iframe>/mi';
$str = '<div>
<iframe src="https://youtube.com"></iframe>
<iframe src="http://www.youtube.com"></iframe>
<iframe class="test" src="http://youtu.be/123"></iframe>
<iframe src="https://yoursite-is-safe-from-gdpr.com"></iframe>
</div>';
$subst = "<div>You must accept cookies before seeing this video content</div>";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php