$re = '/^[^]*?\((\d{3})\)\s*(\d+)-(\d+)\s*\(Main\)[^]*/';
$str = '
(555) 555-5555 (Main)
,
(777) 777-777 (Domestic Fax)
';
$subst = "$1-$2-$3";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php