$re = '/\d*[^\W\d_][^\W_]*/m';
$str = 'win32 backdoor guid:64664646 DNS-lookup h0lla 1234 12.356 jhdsjdhs_jdshjdshds';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php