use strict;
my $str = 'useRs may fly into JFK or laGuardia';
my $regex = qr/((?:\w+\W+){2})(\w)(\w*)(\w)/p;
my $subst = '\\1\\U\\2\\E\\3\\U\\4';
my $result = $str =~ s/$regex/$subst/r;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html