$re = '/(?<="),/';
$str = '["Sender", "mail@text.org"]
[["Sender", "mail@text.org"], ["Date", "Fri, 09 Jun 2017 13:29:22 +0000"]]
[["Sender", "mail@text.org"], ["Date", "Fri, 09 Jun 2017 13:29:22 +0000"], ["Name", "Dude"]]';
$subst = ":";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php