$re = '/\. #([^\\\\.]*)$/m';
$str = '#abc #def This is a test paragraph. #ads I only want to remove the hashtags after the full stop at the end and keep the hashtag at the center. These hashtags should be removed. #ads #ime #abc';
$subst = ".";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php