use strict;
my $str = 'domain.com/folder/random-text-2?A1=A2=A3&A4
domain.com/folder/random-text-2?B1=B2=B3&B4';
my $regex = qr/^(.*\/folder\/[A-Za-z0-9-]*\?)\D+\d+=\D+\d+=\D+\d+&\D+\d+$/mp;
my $subst = '$1REPLACED-1=REPLACED-2=REPLACED-3&REPLACED-4';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html