$re = '/(?<!\\\\)(?:\\\\{2})*(?:"[^\\\\"]*(?:\\\\.[^"\\\\]*)*"|\'[^\\\\\']*(?:\\\\.[^\'\\\\]*)*\')(*SKIP)(*F)|\h+/m';
$str = '2 + 2
2+2
f( " ")
f(" ")
f("Test \\"mystring\\" .")
f("Test \\"mystring\\" .")
f("\' ", " ")
f("\' "," ")';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php