use strict;
my $str = '1 12 end line
10 3 end line
50 444 end line
100 54 end line
1000 5 end line';
my $regex = qr/(^|\G)\d/mp;
my $subst = ' ';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html