$re = '/^
(?=.*?\bone\b)
(?=.*?\btwo\b)
(?=.*?\bthree\b)
(?!\t.*?)
.*
$/xm';
$str = 'only if line contauins one two three it matches
only if line contauins one two three it matches and has no tabs " "
here two whatever
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php