use strict;
my $str = '20100327 15,18,37,39,44,52
20100328 02,08,24,31,33,50
20100330 16,26,27,39,40,46
20100522 05,07,10,11,13,27';
my $regex = qr/\b0+/mp;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html