$re = '/®(?=[^<>]*(?:<[^>]*>[^<]*)*$)/im';
$str = '<img title="Copyright replacement incorrect ®" src="/fileadmin/filexyz.png">
<h1>Copyright replacement correct: ®</h1>
Also correct replacement here: ®
';
$subst = "<sup>®</sup>";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php