const regex = /([aeiouy][a-z]+)|(([qwrtpsdfghjklzxcvbnm]+)([a-z]+))/gi;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('([aeiouy][a-z]+)|(([qwrtpsdfghjklzxcvbnm]+)([a-z]+))', 'gi')
const str = `pig
trash
egg
inbox
eight
hello
yahoo
spoonfull
spleen
flea`;
const subst = `$1$4$3ay`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions