use strict;
my $str = '0109~0123456789ABCDEF0';
my $regex = qr/\b0|([0-F])(?=0*~[0-F]*?\1([0-F]))|~[0-F]*/p;
my $subst = '$2';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html