$re = '/^.*[^\d\r\n](\d+)/m';
$str = '2^64
asdgaf1_hsg534
asdfh23_hsjd12
dgshg_jhfsd86
test
1
testing 1234 testing 1 test4
testing 1234 testing 123';
$subst = "\1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php